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Results of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (important route) and CYP2C9 (slight route). Thus, inhibitors of those isoenzymes could reduce sildenafil clearance and inducers of such isoenzymes may possibly improve sildenafil clearance.Moreover, N-desmethyl metabolite AUC and Cmax values noticeably amp